Do I need to add a placebo to my personal experiment?

Including a placebo in an experiment helps tease out the often powerful psychological effects of being treated.

But often placebos are difficult or impossible to implement, particularly if the treatment has physical manifestations (tingling, scars) that lead to unblinding or there’s no compounding pharmacist is available.

In some cases, unblinded personal experiments without placebos have yielded the same results as large, expensive gold-standard trials with blinding.

Finally, its important to note that placebo effects can be both positive or negative.

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